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Neustem™ Regenerative Injectable
Most injectables occupy space. Neustem™ does something fundamentally different: it asks the body to rebuild the tissue that time, scarring, or genetics took away. Developed and patented by Dr. Simon Ourian at Epione Beverly Hills, this proprietary blend of advanced fillers and growth factors restores volume the moment it is placed, then continues stimulating the skin's own collagen production for months afterward. The result is not a temporary correction. It is regeneration you keep seeing long after the appointment ends.
A Technology That Exists Nowhere Else
Neustem™ was created because Dr. Ourian was not satisfied with what conventional injectables could accomplish. Standard products fill a depleted area beautifully, but they do nothing to improve the quality of the tissue surrounding them. For patients dealing with acne scarring, paper-thin under eye skin, or the structural collapse that follows decades of collagen loss, filling a space was never going to be enough. The tissue itself needed to change.
That challenge produced a category of injectable that does not exist anywhere else in aesthetic medicine. Neustem™ combines the immediate structural support of a high-quality filler with a growth factor complex engineered to trigger the body's own regenerative response. Volume returns instantly. Collagen builds gradually. Skin quality in the treated zone improves in a way that no volumizing product alone has ever been able to deliver.
Because the technology is proprietary to Epione Beverly Hills, patients cannot access it through any other practice, at any price point. Many of the people who travel here from across the world do so specifically because they have exhausted every conventional option available to them locally, and have arrived at the conclusion that a different result requires a fundamentally different approach.
How Neustem Works
Neustem™ is placed with the same anatomical precision that defines every injectable treatment at Epione, but its mechanism unfolds across two distinct timelines. In the first, the product provides immediate volume and structural support to the area treated, lifting depressed scars, replenishing hollowness, and restoring the contour that has been lost. Patients see this change before they leave the treatment room.
The second timeline is the one that sets the technology apart. The growth factor component signals the surrounding tissue to begin producing new collagen and to accelerate its natural repair processes. Over the following weeks and months, the treated area does not simply hold its correction. It improves. Skin becomes thicker, more resilient, and better able to sustain the result on its own, which is why Neustem™ outcomes tend to persist far longer than patients expect from an injectable.
Dr. Ourian selects the formulation, the depth, and the placement pattern for every individual patient, and frequently pairs Neustem™ with Coolaser® resurfacing in the same protocol. The logic is straightforward: Neustem™ rebuilds from beneath while Coolaser® refines the surface above. Treated together, the two technologies produce a result that neither achieves in isolation, which is the foundation of Dr. Ourian's approach to comprehensive facial rejuvenation.
What Can Be Treated and Who It Suits
The applications for Neustem™ are broader than most patients anticipate. Atrophic acne scarring, the pitted and rolling depressions left behind by years of inflammation, responds particularly well because the treatment addresses both the depression itself and the damaged tissue underneath it. Under eye hollowness and the dark circles that accompany it, midface volume loss, jawline definition, temple hollowing, and chin projection are all zones where the technology has produced results that patients describe as unlike anything they had seen previously.
Neustem™ also forms the structural backbone of Dr. Ourian's non-surgical facelift protocol. Rather than treating one concern at a time, he uses the technology across multiple zones in a coordinated plan that restores the underlying architecture of the face, recreating the lifted, triangular proportion that reads as youthful. Because the correction is regenerative rather than purely volumetric, the improvement continues developing well after the initial appointment.
Ideal candidates are adults in good general health who want meaningful structural improvement without surgery and who have realistic expectations about the timeline. Patients who have been told their acne scarring is untreatable, or who have had disappointing filler experiences elsewhere, are among the most common people in Dr. Ourian's consultation room. Every plan begins with a thorough assessment to confirm that Neustem™ is genuinely the right technology for the concern presented.
Neustem for Under Eye Hollows and Dark Circles
The under eye area is the single most difficult region in aesthetic medicine, and it is where Neustem™ has produced its most striking outcomes. The skin here is thinner than anywhere else on the face, the anatomy is unforgiving, and conventional filler placed even slightly incorrectly creates puffiness, discoloration, or a heavy look that patients then spend years trying to reverse. It is the reason results in this zone vary so dramatically from one provider to the next.
Dr. Ourian's under eye protocol pairs Neustem™ with Coolaser® to address both the hollowness casting the shadow and the quality of the skin that makes the shadow visible. Epione published a four-year retrospective study of this approach, reviewing 200 patients drawn from a broader group of more than 2,000 cases, and reported high satisfaction, minimal and temporary side effects, and results measured in years rather than months. Nearly sixty percent of patients seeking this treatment travel from outside the United States.
For patients who have spent a decade concealing dark circles, or who have been told that surgery was the only remaining option, this protocol represents something closer to a resolution than a maintenance routine. No anesthesia is required, no incisions are made, and most people return to their day immediately. The improvement is what patients notice first. The permanence is what brings them back to tell others.
What to Expect During and After Treatment
A Neustem™ appointment typically takes thirty to sixty minutes depending on how many zones are being addressed. Topical numbing is applied in advance, and most patients describe the sensation as mild pressure rather than pain. Dr. Ourian works methodically through each treatment point, assessing the developing result as he goes rather than following a predetermined volume, which is why no two protocols look identical even for patients with similar concerns.
Volume and contour are visible immediately. Mild swelling or occasional bruising can occur and generally resolves within a few days. The regenerative component works on a longer schedule, with collagen improvement becoming apparent over the following four to twelve weeks and continuing to refine beyond that. Patients treated for acne scarring in particular often report that their result at three months is noticeably better than their result at three weeks.
Aftercare is simple. Intense exercise, excessive heat, alcohol, and direct pressure on the treated areas should be avoided for the first twenty-four to forty-eight hours. Some patients achieve their goal in a single session; others, particularly those with extensive scarring or significant structural loss, are best served by a series spaced several weeks apart. Dr. Ourian gives an honest projection at consultation so that expectations and reality align from the outset.
"Dr. Simon Ourian is recognized as one of the world’s leading cosmetic dermatology doctors, known for his precise, natural approach to aesthetic medicine.
His work is defined by restraint, balance and unwavering commitment to safety, delivering results that enhance without appearing treated."
The Californian
Benefits of Neustem
Neustem™ delivers immediate structural correction while triggering the body's own collagen production, producing an outcome that improves rather than fades over the months that follow. Benefits include:
Results that speak for themselves
We perform every treatment with precision and care to achieve the results you want. Achieve stunning results through proven treatments matched to your unique beauty.
Begin Your Consultation at Epione Beverly Hills
Neustem™ cannot be replicated by another practice, another product, or another injector, because it is not simply a formula. It is a technology paired with the anatomical judgment of the physician who developed it. Patients searching for regenerative injectable treatment in Los Angeles will find no shortage of options, and very few of them are attempting anything comparable to what happens in this treatment room.
A consultation with Dr. Ourian is the natural first step, whether you are considering an injectable for the first time or arriving after a disappointing experience elsewhere. Every concern is heard, every question is answered, and a fully personalized plan is developed with no obligation to proceed. The goal is always to ensure that each patient leaves informed, confident, and clear about what the treatment can and cannot accomplish for them specifically.
The results speak clearly on their own. Patients consistently describe Neustem™ as the point at which they stopped managing a problem and started resolving it. Booking a consultation is the single step that begins that process, and the team at Epione Beverly Hills is ready to welcome you.
Frequently asked questions
What exactly is Neustem and how is it different from regular filler?
Neustem™ is Dr. Ourian's patented biostimulatory injectable, combining advanced dermal filler with a growth factor complex. A conventional filler adds volume and eventually metabolizes away. Neustem™ adds volume and simultaneously signals your tissue to produce new collagen, so the treated area physically improves in quality rather than simply holding a correction. It is available only at Epione Beverly Hills.
How long do Neustem results last?
Longer than patients typically expect from an injectable. Because a portion of the result comes from collagen your own body has generated, many patients maintain their outcome for years rather than months. Epione's four-year study of the under eye protocol found results holding well beyond the timeline associated with standard fillers. Duration still varies by area treated, individual metabolism, and the extent of correction required.
Can Neustem really improve acne scars?
Yes, and it is one of the most requested applications. Atrophic scars are depressions in the skin caused by tissue loss, so treating them requires both lifting the depression and rebuilding what was lost beneath it. Dr. Ourian injects Neustem™ into and around the scarred tissue, frequently combining it with Coolaser® resurfacing to refine the surface at the same time. Patients who were told their scarring was permanent are the most common candidates.
Is the treatment painful?
Most patients describe mild pressure with brief moments of stinging, particularly in more sensitive zones such as the under eye area. Topical numbing is applied beforehand and the experience is considerably more comfortable than most first-time patients anticipate. No general anesthesia is involved and no sedation is required
How many sessions will I need?
Many patients see a substantial change after a single session, particularly when treating volume loss or contour. More extensive concerns, such as widespread acne scarring or significant structural collapse, are often better addressed across two or three appointments spaced several weeks apart, which allows the regenerative response from each session to develop before the next. You will receive a realistic projection during your consultation.
Can Neustem be combined with other treatments?
Frequently, and by design. Dr. Ourian regularly pairs Neustem™ with Coolaser® resurfacing so that structure is rebuilt from beneath while texture and tone are refined above. This combination forms the basis of his non-surgical facelift and Invisible Facelift protocols. Combining technologies in one coordinated plan consistently produces a more complete result than treating concerns sequentially.
What should I avoid after treatment?
For the first twenty-four to forty-eight hours, avoid intense exercise, alcohol, excessive heat such as saunas or hot yoga, and direct pressure or massage on the treated areas. Mild swelling and tenderness are normal and usually settle within a few days. Following these guidelines helps the product integrate evenly and gives you the cleanest possible outcome.
Why can I only get Neustem at Epione Beverly Hills?
Because Dr. Simon Ourian developed it. Neustem™ is proprietary technology, not a commercially distributed product, and the protocols behind it were built over years of clinical work with patients whose concerns had not responded to anything else. The technology matters, but so does the judgment applied to it, which is why the treatment is inseparable from the practice that created it.
